Galvus Drug
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Galvus - Vildagliptin
Generic Name : Vildagliptin
Brand Names : Galvus
What is Galvus or Vildagliptin?
Galvus (Vildagliptin) tablets contain the active ingredient vildagliptin, used to treat type 2 or non-insulin dependent diabetes (NIDDM). It works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar (glucose) levels. Galvus is used for people with type 2 diabetes whose blood sugar is not sufficiently controlled by other antidiabetic medicines. It can be added to treatment with metformin; a sulphonylurea, for example gliclazide; or another type of antidiabetic medicine known as a thiazolidinedione, for example pioglitazone or rosiglitazone.
Indications
Galvus is indicated to be used for people with type 2 diabetes diabetes (non-insulin dependent diabetes whose blood sugar is not sufficiently controlled by other antidiabetic medicines.
Dosage
Side effects
The various reported side effects of the drug are:
- Tremor (when used with metformin or a sulphonylurea).
- Headache (when used with metformin or a sulphonylurea).
- Dizziness (when used with metformin or a sulphonylurea).
- Low blood sugar levels (when used with metformin or a sulphonylurea).
- Nausea (when used with metformin).
- Feeling weak (when used with a sulphonylurea).
- Weight gain (when used with a glitazone).
- Swelling of the legs and ankles due to excess fluid retention (when used with a glitazone).
- Fatigue (when used with metformin).
- Constipation (when used with a sulphonylurea).
- Headache (when used with a glitazone).
- Feeling weak (when used with a glitazone).
Drug Interaction
Medicines that increase blood sugar levels as a side effect may make this medicine, and other antidiabetic medicines, less effective at controlling blood sugar. Medicines that can increase blood sugar levels include the following:
- Bronchodilators (beta agonists), eg salbutamol, terbutaline, salmeterol
- Corticosteroids, eg prednisolone
- Levothyroxine
- Thiazide diuretics, eg bendroflumethiazide.
Contraindication
- People over 75 years of age.
- People with mild heart failure.
- People taking ACE inhibitor medicines, eg captopril.
Precaution
- Hypoglycaemia (low blood glucose) has been commonly reported when this medicine is used in combination with metformin or sulphonylurea medicines, eg glimepiride. Symptoms of hypoglycaemia usually occur suddenly and may include cold sweats, cool pale skin, tremor, anxious feeling, unusual tiredness or weakness, confusion, difficulty in concentration, excessive hunger, temporary vision changes, headache, nausea and palpitations. The patient should talk to the doctor or diabetes specialist about this and should make sure what to do if experiences any of these symptoms.
- The ability to concentrate or react may be reduced if the patient has low blood sugar, and this can cause problems driving or operating machinery. Precautions to made when driving.
- People with diabetes have a higher risk of developing foot ulcers and blistering of the skin. It is therefore important to have a good foot care routine. The doctor should be properly consulted if the patient gets any new blisters or ulcers while taking this medicine.
- The patient should consult well before taking the medicine if the patient is Pregnant or is breastfeeding.
- This medicine is not recommended for people receiving dialysis or who have moderate to severe kidney disease.
- This medicine is not recommended for people with suffering from severe heart failure, Type 1 diabetes and Diabetic ketoacidosis.
- This medicine is not recommended for children and adolescents under 18 years of age because it has not been studied in this age group.
- This medicine contains lactose and should not be taken by people with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
- This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
