Gleevec Drug
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Gleevec - Imatinib mesylate
Generic Name : Imatinib mesylate
Brand Names : Gleevec
What is Gleevec or Imatinib mesylate?
Gleevec (imatinib mesylate) is prescribed to treat a type of blood cancer called philadelphia chromosome positive chronic myeloid leukemia (cml). It interferes with the growth of some cancer cells. It is also used to treat certain tumors of the stomach and digestive system.
Indications
Gleevec (imatinib mesylate) is indicated to treat a type of blood cancer called philadelphia chromosome positive chronic myeloid leukemia (cml). It may also used to treat certain tumors of the stomach and digestive system. Gleevec may also be used for other purposes not listed here.
Dosage
Gleevec should be taken exactly as it was prescribed. The patient should not take the medication in larger amounts, or take it for longer than recommended by the doctor. The directions on the prescription label should be followed. This medicine should be taken with a large glass of water. Gleevec should be taken with a meal. To be sure gleevec is not causing harmful effects; blood of the patient will need to be tested on a regular basis. The liver function may also need to be tested. The patient should not miss any scheduled appointments.
Side effects
- Ever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- Nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- Fever, chills, body aches, flu symptoms;
- Black, bloody, or tarry stools;
- Coughing up blood or vomit that looks like coffee grounds;
- Pale skin, easy bruising or bleeding, unusual weakness;
- Feeling short of breath, even with mild exertion;
- Swelling, rapid weight gain; or
- Sudden, severe headache or pain behind the eyes.
- Mild nausea, diarrhea, upset stomach, gas;
- Muscle or joint pain;
- Skin rash;
- Headache, dizziness;
- Stuffy nose, cough, sore throat;
- Depression, sleep problems (insomnia); or
- Tired feeling.
Drug interactions
- Cyclosporine (gengraf, neoral, sandimmune);
- Dexamethasone (decadron, hexadrol);
- Fentanyl (actiq, duragesic, ionsys);
- Sirolimus (rapamune), tacrolimus (prograf);
- St. John's wort;
- A blood thinner such as warfarin (coumadin);
- An antibiotic such as azithromycin (zithromax), ciprofloxacin (cipro), clarithromycin (biaxin), erythromycin (e-mycin, e.e.s., ery-tab, erythrocin), griseofulvin (fulvicin, grifulvin, grisactin), itraconazole (sporanox), ketoconazole (nizoral), metronidazole (flagyl, protostat), rifampin (rifadin, rimactane, rifater);
- Antidepressants such as citalopram (celexa), escitalopram (lexapro), fluoxetine (prozac, sarafem), fluvoxamine (luvox), paroxetine (paxil), or sertraline (zoloft);
- A barbiturate such as amobarbital (amytal) or phenobarbital (luminal, solfoton);
- A calcium channel blocker such as diltiazem (tiazac, cartia, cardizem), nifedipine (procardia, adalat), verapamil (calan, covera, isoptin, verelan), and others;
- Cholesterol-lowering medicines such as lovastatin (mevacor), simvastatin (zocor), pravastatin (pravachol), fluvastatin (lescol), atorvastatin (lipitor), or cerivastatin (baycol).
- Ergot medicine such as ergotamine (ergomar, cafergot) or dihydroergotamine (d.h.e. 45, migranal nasal spray);
- Hiv medication such as nevirapine (viramune), delavirdine (rescriptor), efavirenz (sustiva), indinavir (crixivan), ritonavir (norvir), saquinavir (invirase), or nelfinavir (viracept);
- Sedatives such as alprazolam (xanax) or triazolam (halcion); or
- Seizure medication such as carbamazepine (carbatrol, tegretol) or phenytoin (dilantin).
Overdosage
The patient should seek emergency medical attention if the patient thinks, have used too much of this medicine. Overdose symptoms may include severe muscle cramps.
Contraindications
Before using gleevec, consultation should be done with the doctor if allergic to any drugs, or if having:
- Liver disease;
- Kidney disease;
- Congestive heart failure; or
- A history of stomach ulcer or bleeding.
If the patient has any of these conditions, the patient may need a dose adjustment or special tests to safely take gleevec.
Important
The patient should not use gleevec without telling the doctor if pregnant. It could cause harm to the unborn baby. Use an effective form of birth control.
Before using gleevec, consultation should be done with the doctor if allergic to any drugs, or if having liver disease, kidney disease, congestive heart failure, or a history of stomach ulcer or bleeding.
In case of missing a dose, the medicine should be taken as soon as possible, making sure that it should be taken with a meal and drink a large glass of water. If it is almost time for the next meal, the missed dose should be skipped and should be taken with the next meal. The patient should not take extra medicine to make up the missed dose.
To be sure gleevec is not causing harmful effects, blood of the patient and the liver function will need to be tested on a regular basis. The patient should not miss any scheduled appointments.
